|Application ||FC, WB, E|
|Calculated MW||84483 Da|
|Antigen Region||575-603 aa|
|Other Names||Lysyl oxidase homolog 4, 143-, Lysyl oxidase-like protein 4, Lysyl oxidase-related protein C, LOXL4, LOXC|
|Target/Specificity||This LOXL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-603 amino acids from the C-terminal region of human LOXL4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LOXL4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May modulate the formation of a collagenous extracellular matrix.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Sebban, S., et al. Virchows Arch. 454(1):71-79(2009)
Gorogh, T., et al. Int. J. Oncol. 33(5):1091-1098(2008)
Kim, D.J., et al. Biochem. Biophys. Res. Commun. 373(4):521-527(2008)
Weise, J.B., et al. Int. J. Oncol. 32(2):317-322(2008)
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