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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LOXL4 Antibody (C-term)   

LOXL4 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • FC - LOXL4 Antibody (C-term) AP17245b
    Overlay histogram showing A549 cells stained with AP17245b(green line). The cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with 90% methanol for 10 min. The cells were then icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody (AP17245b, 1:25 dilution) for 60 min at 37ºC. The secondary antibody used was Goat-Anti-Rabbit IgG, DyLight® 488 Conjugated Highly Cross-Adsorbed(1583138) at 1/200 dilution for 40 min at 37ºC. Isotype control antibody (blue line) was rabbit IgG1 (1μg/1x10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed.
  • WB - LOXL4 Antibody (C-term) AP17245b
    All lanes : Anti-LOXL4 Antibody (Center) at 1:2000 dilution Lane 1: Human testis lysate Lane 2: Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 84 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - LOXL4 Antibody (C-term) AP17245b
    LOXL4 Antibody (C-term) (Cat. #AP17245b) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the LOXL4 antibody detected the LOXL4 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession Q96JB6
Other Accession NP_115587.6
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 84483 Da
Antigen Region 575-603 aa
Additional Information
Gene ID 84171
Other Names Lysyl oxidase homolog 4, 143-, Lysyl oxidase-like protein 4, Lysyl oxidase-related protein C, LOXL4, LOXC
Target/Specificity This LOXL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-603 amino acids from the C-terminal region of human LOXL4.
Dilution FC~~1:25
WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLOXL4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LOXL4
Synonyms LOXC
Function May modulate the formation of a collagenous extracellular matrix.
Cellular Location Secreted, extracellular space.
Tissue Location Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage
Research Areas
Citations (0)

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Background

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

References

Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Sebban, S., et al. Virchows Arch. 454(1):71-79(2009)
Gorogh, T., et al. Int. J. Oncol. 33(5):1091-1098(2008)
Kim, D.J., et al. Biochem. Biophys. Res. Commun. 373(4):521-527(2008)
Weise, J.B., et al. Int. J. Oncol. 32(2):317-322(2008)

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$ 295.00
$ 99.00
Cat# AP17245b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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