|Application ||WB, E|
|Calculated MW||133084 Da|
|Antigen Region||617-645 aa|
|Other Names||TBC1 domain family member 1, TBC1D1, KIAA1108|
|Target/Specificity||This TBC1D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 617-645 amino acids from the Central region of human TBC1D1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TBC1D1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM].
Bailey, S.D., et al. Diabetes Care (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)
Must, A., et al. Neuromolecular Med. 11(1):13-19(2009)
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