|Application ||WB, E|
|Other Accession||Q8BUB6, NP_005706.1|
|Calculated MW||47673 Da|
|Antigen Region||291-319 aa|
|Other Names||Uronyl 2-sulfotransferase, 282-, UST, DS2ST|
|Target/Specificity||This UST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-319 amino acids from the C-terminal region of human UST.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UST Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Uher, R., et al. Am J Psychiatry 167(5):555-564(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Xu, D., et al. J. Biol. Chem. 282(11):8356-8367(2007)
Ohtake, S., et al. J. Biol. Chem. 280(47):39115-39123(2005)
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