|Application ||WB, E|
|Other Accession||Q9WV76, NP_006585.2|
|Calculated MW||83260 Da|
|Antigen Region||492-520 aa|
|Other Names||AP-4 complex subunit beta-1, AP-4 adaptor complex subunit beta, Adaptor-related protein complex 4 subunit beta-1, Beta subunit of AP-4, Beta4-adaptin, AP4B1|
|Target/Specificity||This AP4B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 492-520 amino acids from the Central region of human AP4B1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AP4B1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.|
|Cellular Location||Golgi apparatus, trans-Golgi network. Membrane, coated pit Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1; MIM 607244), a medium chain, mu-4 (AP4M1; MIM 602296), and a small chain, sigma-4 (AP4S1; MIM 607243).
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Cayrol, C., et al. Biochem. Biophys. Res. Commun. 298(5):720-730(2002)
Takatsu, H., et al. Biochem. Biophys. Res. Commun. 284(4):1083-1089(2001)
Hirst, J., et al. Mol. Biol. Cell 10(8):2787-2802(1999)
Dell'Angelica, E.C., et al. J. Biol. Chem. 274(11):7278-7285(1999)
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