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>   home   >   Products   >   Primary Antibodies   >   SIGLEC10 Antibody (C-term)   

SIGLEC10 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SIGLEC10 Antibody (C-term) AP17284B
    SIGLEC10 Antibody (C-term) (Cat. #AP17284b) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SIGLEC10 antibody detected the SIGLEC10 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96LC7
Other Accession NP_001164628.1, NP_001164627.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 76592 Da
Antigen Region 667-695 aa
Additional Information
Gene ID 89790
Other Names Sialic acid-binding Ig-like lectin 10, Siglec-10, Siglec-like protein 2, SIGLEC10, SLG2
Target/Specificity This SIGLEC10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 667-695 amino acids from the C-terminal region of human SIGLEC10.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSIGLEC10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms SLG2
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cell membrane; Single-pass type I membrane protein Isoform 5: Secreted.
Tissue Location Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation) Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells
Citations (0)

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SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).


Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Kivi, E., et al. Blood 114(26):5385-5392(2009)
Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) :
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Kitzig, F., et al. Biochem. Biophys. Res. Commun. 296(2):355-362(2002)

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$ 295.00
$ 99.00
Cat# AP17284B
(40 western blots)
Availability: In Stock
Bulk Size
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