|Application ||WB, E|
|Other Accession||NP_001164628.1, NP_001164627.1|
|Calculated MW||76592 Da|
|Antigen Region||667-695 aa|
|Other Names||Sialic acid-binding Ig-like lectin 10, Siglec-10, Siglec-like protein 2, SIGLEC10, SLG2|
|Target/Specificity||This SIGLEC10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 667-695 amino acids from the C-terminal region of human SIGLEC10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SIGLEC10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cell membrane; Single-pass type I membrane protein Isoform 5: Secreted.|
|Tissue Location||Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation) Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells|
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Provided below are standard protocols that you may find useful for product applications.
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Kivi, E., et al. Blood 114(26):5385-5392(2009)
Szafranski, K., et al. Genome Biol. 8 (8), R154 (2007) :
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Kitzig, F., et al. Biochem. Biophys. Res. Commun. 296(2):355-362(2002)
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