|Application ||WB, E|
|Other Accession||NP_001838.2, NP_378667.1|
|Calculated MW||163807 Da|
|Antigen Region||830-859 aa|
|Other Names||Collagen alpha-6(IV) chain, COL4A6|
|Target/Specificity||This COL4A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 830-859 amino acids from the Central region of human COL4A6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COL4A6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|
|Cellular Location||Secreted, extracellular space, extracellular matrix, basement membrane|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene.
Romero, R., et al. Am. J. Obstet. Gynecol. (2010) In press :
Bailey, S.D., et al. Diabetes Care (2010) In press :
Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Skovbjerg, H., et al. BMC Cancer 9, 136 (2009) :
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