CADM3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8N126 |
Other Accession | NP_001120645.1, NP_067012.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 43300 Da |
Antigen Region | 158-186 aa |
Gene ID | 57863 |
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Other Names | Cell adhesion molecule 3, Brain immunoglobulin receptor, Immunoglobulin superfamily member 4B, IgSF4B, Nectin-like protein 1, NECL-1, Synaptic cell adhesion molecule 3, SynCAM3, TSLC1-like protein 1, TSLL1, CADM3, IGSF4B, NECL1, SYNCAM3, TSLL1 |
Target/Specificity | This CADM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-186 amino acids from the Central region of human CADM3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CADM3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CADM3 |
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Synonyms | IGSF4B, NECL1, SYNCAM3, TSLL1 |
Function | Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q99N28}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q99N28} Cell junction {ECO:0000250|UniProtKB:Q99N28} |
Tissue Location | Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).
References
Yin, B., et al. Chin. Med. Sci. J. 25(2):100-104(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Raveh, S., et al. J. Cell. Biochem. 108(1):326-336(2009)
Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)
Dong, X., et al. J. Biol. Chem. 281(15):10610-10617(2006)
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