|Application ||WB, E|
|Other Accession||NP_001120645.1, NP_067012.1|
|Calculated MW||43300 Da|
|Antigen Region||158-186 aa|
|Other Names||Cell adhesion molecule 3, Brain immunoglobulin receptor, Immunoglobulin superfamily member 4B, IgSF4B, Nectin-like protein 1, NECL-1, Synaptic cell adhesion molecule 3, SynCAM3, TSLC1-like protein 1, TSLL1, CADM3, IGSF4B, NECL1, SYNCAM3, TSLL1|
|Target/Specificity||This CADM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-186 amino acids from the Central region of human CADM3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CADM3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||IGSF4B, NECL1, SYNCAM3, TSLL1|
|Function||Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity).|
|Cellular Location||Cell junction. Cell membrane; Single-pass type I membrane protein Note=Localized at the cell-cell attached sites of the plasma membrane.|
|Tissue Location||Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum.|
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Provided below are standard protocols that you may find useful for product applications.
IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).
Yin, B., et al. Chin. Med. Sci. J. 25(2):100-104(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Raveh, S., et al. J. Cell. Biochem. 108(1):326-336(2009)
Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)
Dong, X., et al. J. Biol. Chem. 281(15):10610-10617(2006)
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