|Application ||WB, E|
|Calculated MW||74107 Da|
|Antigen Region||277-305 aa|
|Other Names||RNA polymerase I-specific transcription initiation factor RRN3, Transcription initiation factor IA, TIF-IA, RRN3, TIFIA|
|Target/Specificity||This RRN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-305 amino acids from the Central region of human RRN3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RRN3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).|
|Cellular Location||Nucleus, nucleolus|
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Provided below are standard protocols that you may find useful for product applications.
Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).
Bierhoff, H., et al. Mol. Cell. Biol. 28(16):4988-4998(2008)
Amit, M., et al. BMC Mol. Biol. 8, 109 (2007) :
Mayer, C., et al. Genes Dev. 18(4):423-434(2004)
Hirschler-Laszkiewicz, I., et al. J. Biol. Chem. 278(21):18953-18959(2003)
Zhao, J., et al. Mol. Cell 11(2):405-413(2003)
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