|Application ||WB, E|
|Other Accession||NP_001628.1, NP_001170977.1|
|Calculated MW||65105 Da|
|Antigen Region||168-197 aa|
|Other Names||Acyloxyacyl hydrolase, Acyloxyacyl hydrolase small subunit, Acyloxyacyl hydrolase large subunit, AOAH|
|Target/Specificity||This AOAH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the Central region of human AOAH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AOAH Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides.|
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Provided below are standard protocols that you may find useful for product applications.
This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Pelak, K., et al. J. Infect. Dis. 201(8):1141-1149(2010)
Barnes, K.C., et al. J. Allergy Clin. Immunol. 118(1):70-77(2006)
Coulthard, M.G., et al. Infect. Immun. 64(5):1510-1515(1996)
Staab, J.F., et al. J. Biol. Chem. 269(38):23736-23742(1994)
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