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RBM23 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86U06 |
| Other Accession | NP_001070820.1, NP_001070819.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48731 Da |
| Antigen Region | 128-157 aa |
| Gene ID | 55147 |
|---|---|
| Other Names | Probable RNA-binding protein 23, RNA-binding motif protein 23, RNA-binding region-containing protein 4, Splicing factor SF2, RBM23, RNPC4 |
| Target/Specificity | This RBM23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-157 amino acids from the Central region of human RBM23. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RBM23 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RBM23 {ECO:0000303|PubMed:31693891, ECO:0000312|HGNC:HGNC:20155} |
|---|---|
| Function | RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343). |
| Cellular Location | Nucleus. |
| Tissue Location | Highly expressed in placenta, liver, skeletal muscle, heart and kidney (PubMed:15694343). Expressed at lower levels in the colon, thymus, spleen, small intestine and lung (PubMed:15694343). |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Stelzl, U., et al. Cell 122(6):957-968(2005)
Dowhan, D.H., et al. Mol. Cell 17(3):429-439(2005)
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