|Application ||WB, E|
|Other Accession||Q91ZR2, NP_001096045.1, NP_001138899.1|
|Calculated MW||68894 Da|
|Antigen Region||485-514 aa|
|Other Names||Sorting nexin-18, SH3 and PX domain-containing protein 3B, Sorting nexin-associated Golgi protein 1, SNX18, SH3PXD3B, SNAG1|
|Target/Specificity||This SNX18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 485-514 amino acids from the C-terminal region of human SNX18.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNX18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. Promotes DNM2 location at the plasma membrane.|
|Cellular Location||Endomembrane system; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Partially colocalized with clathrin and dynamin at the cell membrane. Transiently recruited to clathrin- coated pits at a late stage of clathrin-coated vesicle formation|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene.
Park, J., et al. J. Cell. Sci. 123 (PT 10), 1742-1750 (2010) :
Voss, M., et al. BMC Immunol. 10, 53 (2009) :
Haberg, K., et al. J. Cell. Sci. 121 (PT 9), 1495-1505 (2008) :
Thornhill, P.B., et al. FEBS Lett. 581(23):4455-4462(2007)
Seet, L.F., et al. Biochim. Biophys. Acta 1761(8):878-896(2006)
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