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SIX2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SIX2 Antibody (Center) AP17338C
    SIX2 Antibody (Center) (Cat. #AP17338c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SIX2 antibody detected the SIX2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NPC8
Other Accession Q27350, Q62232, Q9I8H0, Q62231, Q15475, Q6NZ04, Q6DHF9, NP_058628.3
Reactivity Human
Predicted Zebrafish, Mouse, Xenopus, Drosophila
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 32286 Da
Antigen Region 89-119 aa
Additional Information
Gene ID 10736
Other Names Homeobox protein SIX2, Sine oculis homeobox homolog 2, SIX2
Target/Specificity This SIX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-119 amino acids from the Central region of human SIX2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSIX2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIX2
Function Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration.
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q62232}.
Tissue Location Strongly expressed in skeletal muscle. Expressed in Wilms' tumor and in the cap mesenchyme of fetal kidney (at protein level).
Research Areas
Citations (0)

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This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development.


Kumar, J.P. Cell. Mol. Life Sci. 66(4):565-583(2009)
Weber, S., et al. J. Am. Soc. Nephrol. 19(5):891-903(2008)
Christensen, K.L., et al. Adv. Cancer Res. 101, 93-126 (2008) :
Buller, C., et al. Hum. Mol. Genet. 10(24):2775-2781(2001)
Boucher, C.A., et al. Gene 247 (1-2), 145-151 (2000) :

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$ 295.00
$ 99.00
Cat# AP17338C
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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