|Application ||WB, E|
|Calculated MW||54303 Da|
|Antigen Region||102-130 aa|
|Other Names||One cut domain family member 2, Hepatocyte nuclear factor 6-beta, HNF-6-beta, One cut homeobox 2, Transcription factor ONECUT-2, OC-2, ONECUT2, HNF6B|
|Target/Specificity||This ONECUT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the N-terminal region of human ONECUT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ONECUT2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation.
Furuno, K., et al. Genes Immun. 9(4):302-308(2008)
Pike, B.L., et al. Leukemia 22(5):1035-1043(2008)
Rauch, T., et al. Cancer Res. 66(16):7939-7947(2006)
Jacquemin, P., et al. Biochem. Biophys. Res. Commun. 285(5):1200-1205(2001)
Jacquemin, P., et al. J. Biol. Chem. 274(5):2665-2671(1999)
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