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NPLOC4 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NPLOC4 Antibody (C-term) AP17356b
    NPLOC4 Antibody (C-term) (Cat. #AP17356b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the NPLOC4 antibody detected the NPLOC4 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8TAT6
Other Accession Q9ES54, P60670, NP_060391.2
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68120 Da
Antigen Region 456-484 aa
Additional Information
Gene ID 55666
Other Names Nuclear protein localization protein 4 homolog, Protein NPL4, NPLOC4, KIAA1499, NPL4
Target/Specificity This NPLOC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-484 amino acids from the C-terminal region of human NPLOC4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNPLOC4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPLOC4
Synonyms KIAA1499, NPL4
Function The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).
Cellular Location Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus Note=Associated with the endoplasmic reticulum and nuclear
Tissue Location Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver
Research Areas
Citations (0)

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Background

The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).

References

Liu, F., et al. PLoS Genet. 6, E1000934 (2010) :
Lass, A., et al. Exp. Cell Res. 314(14):2715-2723(2008)
McConnell, E., et al. Biochem. Biophys. Res. Commun. 355(4):1087-1090(2007)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
Botta, A., et al. Gene 275(1):39-46(2001)

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$ 295.00
$ 99.00
Cat# AP17356b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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