|Application ||WB, E|
|Other Accession||Q9CWM4, Q3SZE2, NP_002613.2|
|Calculated MW||14210 Da|
|Antigen Region||86-113 aa|
|Other Names||Prefoldin subunit 1, PFDN1, PFD1|
|Target/Specificity||This PFDN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-113 amino acids from the C-terminal region of human PFDN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PFDN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Stirling, P.C., et al. J. Biol. Chem. 281(11):7012-7021(2006)
Stelzl, U., et al. Cell 122(6):957-968(2005)
Simons, C.T., et al. J. Biol. Chem. 279(6):4196-4203(2004)
Gstaiger, M., et al. Science 302(5648):1208-1212(2003)
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