|Application ||WB, E|
|Calculated MW||23307 Da|
|Antigen Region||169-196 aa|
|Other Names||Sclerostin domain-containing protein 1, Ectodermal BMP inhibitor, Ectodin, Uterine sensitization-associated gene 1 protein, USAG-1, SOSTDC1, USAG1|
|Target/Specificity||This SOSTDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-196 amino acids from the C-terminal region of human SOSTDC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SOSTDC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.|
|Tissue Location||Highly expressed in kidney and weakly in lung.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.
Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010) :
Ohshima, J., et al. Genes Chromosomes Cancer 48(12):1037-1050(2009)
Blish, K.R., et al. Mol. Biol. Cell 19(2):457-464(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Yanagita, M. Cytokine Growth Factor Rev. 16(3):309-317(2005)
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