|Application ||WB, E|
|Other Accession||Q8VDG7, NP_000428.2|
|Calculated MW||44036 Da|
|Antigen Region||249-276 aa|
|Other Names||Platelet-activating factor acetylhydrolase 2, cytoplasmic, Serine-dependent phospholipase A2, SD-PLA2, hSD-PLA2, PAFAH2|
|Target/Specificity||This PAFAH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-276 amino acids from the Central region of human PAFAH2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAFAH2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.|
|Tissue Location||Broadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.
Schmidt, E.B., et al. Atherosclerosis 196(1):420-424(2008)
Umemura, K., et al. Stroke 38(3):1063-1068(2007)
Unno, N., et al. J. Surg. Res. 134(1):36-43(2006)
Marques, M., et al. J. Invest. Dermatol. 119(4):913-919(2002)
Min, J.H., et al. Biochemistry 40(15):4539-4549(2001)
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