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PAFAH2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PAFAH2 Antibody (Center) AP17398c
    PAFAH2 Antibody (Center) (Cat. #AP17398c) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the PAFAH2 antibody detected the PAFAH2 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q99487
Other Accession Q8VDG7, NP_000428.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44036 Da
Antigen Region 249-276 aa
Additional Information
Gene ID 5051
Other Names Platelet-activating factor acetylhydrolase 2, cytoplasmic, Serine-dependent phospholipase A2, SD-PLA2, hSD-PLA2, PAFAH2
Target/Specificity This PAFAH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-276 amino acids from the Central region of human PAFAH2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPAFAH2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAFAH2
Function Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.
Cellular Location Cytoplasm.
Tissue Location Broadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex
Research Areas
Citations (0)

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Background

This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.

References

Schmidt, E.B., et al. Atherosclerosis 196(1):420-424(2008)
Umemura, K., et al. Stroke 38(3):1063-1068(2007)
Unno, N., et al. J. Surg. Res. 134(1):36-43(2006)
Marques, M., et al. J. Invest. Dermatol. 119(4):913-919(2002)
Min, J.H., et al. Biochemistry 40(15):4539-4549(2001)

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$ 295.00
$ 99.00
Cat# AP17398c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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