|Application ||WB, E|
|Other Accession||Q2PFN5, NP_005833.1|
|Calculated MW||34688 Da|
|Antigen Region||6-35 aa|
|Other Names||Protein sprouty homolog 2, Spry-2, SPRY2|
|Target/Specificity||This SPRY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-35 amino acids from the N-terminal region of human SPRY2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPRY2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor)|
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This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq].
Ma, Y., et al. Cancer Lett. 298(2):150-158(2010)
Holgren, C., et al. Oncogene 29(38):5241-5253(2010)
Jagomagi, T., et al. Eur. J. Oral Sci. 118(3):213-220(2010)
Chitra, E., et al. Retrovirology 7, 62 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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