PTPN23 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9H3S7 |
Other Accession | NP_056281.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 178974 Da |
Antigen Region | 1181-1209 aa |
Gene ID | 25930 |
---|---|
Other Names | Tyrosine-protein phosphatase non-receptor type 23, His domain-containing protein tyrosine phosphatase, HD-PTP, Protein tyrosine phosphatase TD14, PTP-TD14, PTPN23, KIAA1471 |
Target/Specificity | This PTPN23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1181-1209 amino acids from the C-terminal region of human PTPN23. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PTPN23 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PTPN23 |
---|---|
Synonyms | KIAA1471 |
Function | Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). |
Cellular Location | Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
PTPN23 may act as a negative regulator of Ras-mediated mitogenic activity.
References
Mariotti, M., et al. Int. J. Biochem. Cell Biol. 41(3):687-693(2009)
Mariotti, M., et al. Cancer Lett. 273(1):155-163(2009)
Gingras, M.C., et al. PLoS ONE 4 (4), E5105 (2009) :
Castiglioni, S., et al. Biochem. Biophys. Res. Commun. 364(3):534-539(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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