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TACC1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O75410 |
| Other Accession | NP_001139688.1, NP_001116296.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 87794 Da |
| Antigen Region | 117-145 aa |
| Gene ID | 6867 |
|---|---|
| Other Names | Transforming acidic coiled-coil-containing protein 1, Gastric cancer antigen Ga55, Taxin-1, TACC1, KIAA1103 |
| Target/Specificity | This TACC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-145 amino acids from the N-terminal region of human TACC1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TACC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TACC1 |
|---|---|
| Synonyms | KIAA1103 |
| Function | Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. |
| Cellular Location | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. [Isoform 10]: Cytoplasm |
| Tissue Location | Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene.
References
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Guyot, R., et al. BMC Mol. Biol. 11, 3 (2010) :
Ghayad, S.E., et al. J. Mol. Endocrinol. 42(2):87-103(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Lauffart, B., et al. Dev. Dyn. 235(6):1638-1647(2006)
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