|Application ||WB, E|
|Calculated MW||83354 Da|
|Antigen Region||577-607 aa|
|Other Names||LETM1 and EF-hand domain-containing protein 1, mitochondrial, Leucine zipper-EF-hand-containing transmembrane protein 1, LETM1|
|Target/Specificity||This LETM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 577-607 amino acids from the C-terminal region of human LETM1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LETM1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248).|
|Cellular Location||Mitochondrion inner membrane; Single- pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19.
Jiang, D., et al. Science 326(5949):144-147(2009)
Piao, L., et al. Cell. Signal. 21(5):767-777(2009)
Piao, L., et al. Cancer Res. 69(8):3397-3404(2009)
Tamai, S., et al. J. Cell. Sci. 121 (PT 15), 2588-2600 (2008) :
Dimmer, K.S., et al. Hum. Mol. Genet. 17(2):201-214(2008)
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