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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AMICA1 Antibody (N-term)   

AMICA1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - AMICA1 Antibody (N-term) AP17456A
    AMICA1 Antibody (N-term) (Cat. #AP17456a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the AMICA1 antibody detected the AMICA1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q86YT9
Other Accession NP_001091996.1, NP_694938.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44339 Da
Antigen Region 43-72 aa
Additional Information
Gene ID 120425
Other Names Junctional adhesion molecule-like, Adhesion molecule interacting with CXADR antigen 1, Dendritic cell-specific protein CREA7-1, AMICA1, JAML
Target/Specificity This AMICA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from the N-terminal region of human AMICA1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAMICA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name JAML (HGNC:19084)
Synonyms AMICA1
Function Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Cellular Location Cell membrane; Single-pass type I membrane protein Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515)
Tissue Location Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).
Research Areas
Citations (0)

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Background

AMICA1 may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Luissint, A.C., et al. J. Cell Biol. 183(6):1159-1173(2008)
Zen, K., et al. Mol. Biol. Cell 16(6):2694-2703(2005)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Moog-Lutz, C., et al. Blood 102(9):3371-3378(2003)

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$ 295.00
$ 99.00
Cat# AP17456A
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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