|Application ||WB, E|
|Other Accession||P54287, P54286, P54285, NP_000716.2|
|Predicted||Mouse, Rabbit, Rat|
|Calculated MW||54532 Da|
|Antigen Region||407-434 aa|
|Other Names||Voltage-dependent L-type calcium channel subunit beta-3, CAB3, Calcium channel voltage-dependent subunit beta 3, CACNB3, CACNLB3|
|Target/Specificity||This CACNB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-434 amino acids from the C-terminal region of human CACNB3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CACNB3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.|
|Tissue Location||Expressed mostly in brain, smooth muscle and ovary|
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Provided below are standard protocols that you may find useful for product applications.
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Zhang, Y., et al. J. Biol. Chem. 285(4):2527-2536(2010)
Bernardo, J.F., et al. Can. J. Physiol. Pharmacol. 87(7):522-530(2009)
Voss, M., et al. BMC Immunol. 10, 53 (2009) :
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Vendel, A.C., et al. J. Neurosci. 26(10):2635-2644(2006)
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