|Application ||WB, E|
|Other Accession||NP_001180259.1, NP_001180258.1|
|Calculated MW||93572 Da|
|Antigen Region||215-242 aa|
|Other Names||Aminopeptidase O, AP-O, 3411-, AOPEP, C9orf3, ONPEP|
|Target/Specificity||This AOPEP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-242 amino acids from the N-terminal region of human AOPEP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AOPEP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.|
|Tissue Location||Predominantly expressed in pancreas, placenta, liver, testis and heart. Expressed at lower level in brain, lung and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants.
Diaz-Perales, A., et al. J. Biol. Chem. 280(14):14310-14317(2005)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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