|Application ||WB, E|
|Calculated MW||60724 Da|
|Antigen Region||496-525 aa|
|Other Names||Cytochrome P450 4V2, 11413-, Docosahexaenoic acid omega-hydroxylase CYP4V2, CYP4V2|
|Target/Specificity||This CYP4V2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 496-525 amino acids from the C-terminal region of human CYP4V2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYP4V2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega- hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20- hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein|
|Tissue Location||Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids.
Yokoi, Y., et al. Acta Ophthalmol 88(5):607-609(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Pelak, K., et al. J. Infect. Dis. 201(8):1141-1149(2010)
Nakano, M., et al. Drug Metab. Dispos. 37(11):2119-2122(2009)
Li, Y., et al. J. Thromb. Haemost. 7(11):1802-1808(2009)
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