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AGTPBP1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UPW5 |
| Other Accession | NP_056054.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 138448 Da |
| Antigen Region | 363-392 aa |
| Gene ID | 23287 |
|---|---|
| Other Names | Cytosolic carboxypeptidase 1, 3417-, ATP/GTP-binding protein 1, Nervous system nuclear protein induced by axotomy protein 1 homolog, AGTPBP1, CCP1, KIAA1035, NNA1 |
| Target/Specificity | This AGTPBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 363-392 amino acids from the N-terminal region of human AGTPBP1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AGTPBP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AGTPBP1 (HGNC:17258) |
|---|---|
| Function | Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:22170066, PubMed:24022482, PubMed:30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta- tubulin (PubMed:22170066, PubMed:24022482, PubMed:30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:24022482). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). |
| Cellular Location | Cytoplasm. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q641K1}. Nucleus Mitochondrion {ECO:0000250|UniProtKB:Q641K1}. Note=Localizes in both the cytoplasm and nuclei of interphase and dividing cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.
References
Lim, J., et al. Cell 125(4):801-814(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Fernandez-Gonzalez, A., et al. Science 295(5561):1904-1906(2002)
Harris, A., et al. Mol. Cell. Neurosci. 16(5):578-596(2000)
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