|Application ||WB, E|
|Calculated MW||39332 Da|
|Antigen Region||94-120 aa|
|Other Names||G-protein coupled receptor 78, GPR78|
|Target/Specificity||This GPR78 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-120 amino acids from the Central region of human GPR78.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPR78 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
Zhu, X., et al. World J. Gastroenterol. 15(39):4958-4961(2009)
Yosifova, A., et al. J Affect Disord 117 (1-2), 87-97 (2009) :
Jones, P.G., et al. Biochim. Biophys. Acta 1770(6):890-901(2007)
Underwood, S.L., et al. Mol. Psychiatry 11(4):384-394(2006)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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