|Application ||WB, E|
|Calculated MW||39332 Da|
|Antigen Region||94-120 aa|
|Other Names||G-protein coupled receptor 78, GPR78|
|Target/Specificity||This GPR78 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-120 amino acids from the Central region of human GPR78.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPR78 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney.|
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Provided below are standard protocols that you may find useful for product applications.
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
Zhu, X., et al. World J. Gastroenterol. 15(39):4958-4961(2009)
Yosifova, A., et al. J Affect Disord 117 (1-2), 87-97 (2009) :
Jones, P.G., et al. Biochim. Biophys. Acta 1770(6):890-901(2007)
Underwood, S.L., et al. Mol. Psychiatry 11(4):384-394(2006)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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