|Application ||WB, E|
|Other Accession||F1LZF0, Q8JZP3, NP_001154993.1|
|Calculated MW||65975 Da|
|Antigen Region||77-103 aa|
|Other Names||Kelch-like protein 2, Actin-binding protein Mayven, KLHL2|
|Target/Specificity||This KLHL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-103 amino acids from the N-terminal region of human KLHL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KLHL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection. Cell projection, lamellipodium. Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity)|
|Tissue Location||Ubiquitous. Detected throughout the brain.|
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Provided below are standard protocols that you may find useful for product applications.
KLHL2 may play a role in organizing the actin cytoskeleton of the brain cells.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Williams, S.K., et al. J. Neurosci. Res. 81(5):622-631(2005)
Bu, X., et al. Oncogene 24(14):2398-2409(2005)
Soltysik-Espanola, M., et al. Mol. Biol. Cell 10(7):2361-2375(1999)
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