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KLHL2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - KLHL2 Antibody (N-term) AP17585a
    KLHL2 Antibody (N-term) (Cat. #AP17585a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KLHL2 antibody detected the KLHL2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95198
Other Accession F1LZF0, Q8JZP3, NP_001154993.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 65975 Da
Antigen Region 77-103 aa
Additional Information
Gene ID 11275
Other Names Kelch-like protein 2, Actin-binding protein Mayven, KLHL2
Target/Specificity This KLHL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-103 amino acids from the N-terminal region of human KLHL2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKLHL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLHL2
Function Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.
Cellular Location Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection. Cell projection, lamellipodium. Cytoplasm, cytosol. Note=A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity)
Tissue Location Ubiquitous. Detected throughout the brain.
Research Areas
Citations (0)

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KLHL2 may play a role in organizing the actin cytoskeleton of the brain cells.


Rose, J. Phd, et al. Mol. Med. (2010) In press :
Williams, S.K., et al. J. Neurosci. Res. 81(5):622-631(2005)
Bu, X., et al. Oncogene 24(14):2398-2409(2005)
Soltysik-Espanola, M., et al. Mol. Biol. Cell 10(7):2361-2375(1999)

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$ 295.00
$ 99.00
Cat# AP17585a
(40 western blots)
Availability: In Stock
Bulk Size
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