|Application ||WB, E|
|Calculated MW||62225 Da|
|Antigen Region||404-430 aa|
|Other Names||Phosphoglucomutase-like protein 5, Aciculin, Phosphoglucomutase-related protein, PGM-RP, PGM5, PGMRP|
|Target/Specificity||This PGM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-430 amino acids from the C-terminal region of human PGM5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PGM5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity.|
|Cellular Location||Cell junction, adherens junction. Cytoplasm, cytoskeleton. Note=Adherens-type cellular junctions. Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments|
|Tissue Location||Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component. Low levels are present in liver, kidney, skin and brain (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Phosphoglucomutases (EC 188.8.131.52.), such as PGM5, are phosphotransferases involved in interconversion of glucose-1-phosphate and glucose-6-phosphate. PGM activity is essential in formation of carbohydrates from glucose-6-phosphate and in formation of glucose-6-phosphate from galactose and glycogen (Edwards et al., 1995 [PubMed 8586438]).
Wakayama, Y., et al. Acta Neuropathol. 99(6):654-662(2000)
Moiseeva, E.P., et al. Eur. J. Biochem. 248(3):634-643(1997)
Moiseeva, E.P., et al. Eur. J. Biochem. 235 (1-2), 103-113 (1996) :
Edwards, Y.H., et al. Genomics 30(2):350-353(1995)
Belkin, A.M., et al. Exp. Cell Res. 221(1):132-140(1995)
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