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RNF219 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q5W0B1 |
| Other Accession | NP_078822.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 81116 Da |
| Antigen Region | 275-302 aa |
| Gene ID | 79596 |
|---|---|
| Other Names | RING finger protein 219, RNF219, C13orf7 |
| Target/Specificity | This RNF219 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-302 amino acids from the Central region of human RNF219. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RNF219 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OBI1 (HGNC:20308) |
|---|---|
| Synonyms | C13orf7, RNF219 |
| Function | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). |
| Cellular Location | Chromosome. Note=Association to chromatin is cell cycle-regulated, absent from mitotic chromosomes, is associated with chromatin from G1 and partially released from chromatin from mid S-phase |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
C13orf7 is phosphorylated upon DNA damage, probably by ATM or ATR. However, the function of C13orf7 remains unknown.
References
Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010) :
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Dunham, A., et al. Nature 428(6982):522-528(2004)
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