|Application ||WB, E|
|Other Accession||Q3MHE8, NP_001171313.1|
|Calculated MW||69811 Da|
|Antigen Region||453-480 aa|
|Other Names||Signal recognition particle receptor subunit alpha, SR-alpha, Docking protein alpha, DP-alpha, SRPR|
|Target/Specificity||This SRPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-480 amino acids from the C-terminal region of human SRPR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SRPR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain|
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Provided below are standard protocols that you may find useful for product applications.
The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants.
Janin, N., et al. Hum. Genet. 88(5):583-585(1992)
Hortsch, M., et al. Biochem. Biophys. Res. Commun. 150(1):111-117(1988)
Hortsch, M., et al. Nucleic Acids Res. 16(1):361-362(1988)
Tajima, S., et al. J. Cell Biol. 103(4):1167-1178(1986)
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