|Application ||WB, E|
|Other Accession||Q9JLH8, Q0VC48, NP_037485.2|
|Calculated MW||39335 Da|
|Antigen Region||150-176 aa|
|Other Names||Tropomodulin-4, Skeletal muscle tropomodulin, Sk-Tmod, TMOD4|
|Target/Specificity||This TMOD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-176 amino acids from the Central region of human TMOD4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TMOD4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.|
|Cellular Location||Cytoplasm, cytoskeleton. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).|
|Tissue Location||Highly expressed in skeletal muscle.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
TMOD4 blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Cox, P.R., et al. BMC Genomics 2 (1), 7 (2001) :
Cox, P.R., et al. Genomics 63(1):97-107(2000)
Almenar-Queralt, A., et al. J. Biol. Chem. 274(40):28466-28475(1999)
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