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CCIN Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CCIN Antibody (Center) AP17618c
    All lanes : Anti-CCIN Antibody (Center) at 1:1000 dilution Lane 1: human testis lysate Lane 2: HL-60 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 67 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q13939
Other Accession Q5XI58, Q8CDE2, Q28068, NP_005884.2
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 373-400 aa
Additional Information
Other Names Calicin, CCIN
Target/Specificity This CCIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-400 amino acids from the Central region of human CCIN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCIN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCIN
Function Possible morphogenetic cytoskeletal element in spermiogenic differentiation.
Cellular Location Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure tightly associated to the nucleus
Tissue Location Testis. Not detectable or shows a drastically altered pattern of arrangement in the heads of malformed spermatozoa. EMBL; AF333334; AAK20829.1; -; mRNA EMBL; Z46967; CAA87088.1; -; mRNA CCDS; CCDS6599.1; - PIR; I37216; I37216 RefSeq; NP_005884.2; NM_005893.2 UniGene; Hs.115460; - ProteinModelPortal; Q13939; - SMR; Q13939; - BioGrid; 107324; 2 STRING; 9606.ENSP00000334996; - iPTMnet; Q13939; - PhosphoSitePlus; Q13939; - BioMuta; CCIN; - DMDM; 143811369; - PaxDb; Q13939; - PeptideAtlas; Q13939; - PRIDE; Q13939; - ProteomicsDB; 59761; - DNASU; 881; - Ensembl; ENST00000335119; ENSP00000334996; ENSG00000185972 GeneID; 881; - KEGG; hsa:881; - CTD; 881; - EuPathDB; HostDB:ENSG00000185972.5; - GeneCards; CCIN; - H-InvDB; HIX0008029; - HGNC; HGNC:1568; CCIN MIM; 603960; gene neXtProt; NX_Q13939; - OpenTargets; ENSG00000185972; - PharmGKB; PA26140; - eggNOG; KOG4441; Eukaryota eggNOG; ENOG410XNX8; LUCA GeneTree; ENSGT00800000124141; - HOGENOM; HOG000060293; - HOVERGEN; HBG003874; - InParanoid; Q13939; - OMA; RCPPVIF; - OrthoDB; EOG091G03HW; - PhylomeDB; Q13939; - TreeFam; TF331981; - ChiTaRS; CCIN; human GenomeRNAi; 881; - PRO; PR:Q13939; - Proteomes; UP000005640; Chromosome 9 Bgee; ENSG00000185972; - CleanEx; HS_CCIN; - ExpressionAtlas; Q13939; baseline and differential Genevisible; Q13939; HS GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IBA:GO_Central GO; GO:0033150; C:cytoskeletal calyx; IEA:UniProtKB-SubCell GO; GO:0005634; C:nucleus; HDA:UniProtKB GO; GO:0003779; F:actin binding; IBA:GO_Central GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW GO; GO:0016567; P:protein ubiquitination; IEA:GOC GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW Gene3D; 2.120.10.80; -; 2 InterPro; IPR011705; BACK InterPro; IPR017096; BTB-kelch_protein InterPro; IPR000210; BTB/POZ_dom InterPro; IPR015915; Kelch-typ_b-propeller InterPro; IPR006652; Kelch_1 InterPro; IPR011333; SKP1/BTB/POZ_sf Pfam; PF07707; BACK; 1 Pfam; PF00651; BTB; 1 Pfam; PF01344; Kelch_1; 1 PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1 SMART; SM00875; BACK; 1 SMART; SM00225; BTB; 1 SMART; SM00612; Kelch; 3 SUPFAM; SSF117281; SSF117281; 2 SUPFAM; SSF54695; SSF54695; 1 PROSITE; PS50097; BTB; 1 2: Evidence at transcript level; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Kelch repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Spermatogenesis CHAIN 1 588 Calicin /FTId=PRO_0000119067 DOMAIN 12 124 BTB. {ECO:0000255|PROSITE- ProRule:PRU00037} DOMAIN 133 235 BACK REPEAT 280 327 Kelch 1 REPEAT 328 375 Kelch 2 REPEAT 377 423 Kelch 3 REPEAT 425 475 Kelch 4 REPEAT 476 525 Kelch 5 REPEAT 526 580 Kelch 6 MOD_RES 149 149 Phosphoserine {ECO:0000250|UniProtKB:Q5XI58} VARIANT 75 75 S -> N (in dbSNP:rs34789048) /FTId=VAR_050039 CONFLICT 226 226 N -> S (in Ref. 1; AAK20829) CONFLICT 433 433 C -> W (in Ref. 2; CAA87088) CONFLICT 490 490 I -> N (in Ref. 1; AAK20829) SEQUENCE 588 AA; 66582 MW; 8EEB910611BBA98B CRC64; MKLEFTEKNY NSFVLQNLNR QRKRKEYWDM ALSVDNHVFF AHRNVLAAVS PLVRSLISSN DMKTADELFI TIDTSYLSPV TVDQLLDYFY SGKVVISEQN VEELLRGAQY FNTPRLRVHC NDFLIKSICR ANCLRYLFLA ELFELKEVSD VAYSGIRDNF HYWASPEGSM HFMRCPPVIF GRLLRDENLH VLNEDQALSA LINWVYFRKE DREKYFKKFF NYINLNAVSN KTLVFASNKL VGMENTSSHT TLIESVLMDR KQERPCSLLV YQRKGALLDS VVILGGQKAH GQFNDGVFAY IIQENLWMKL SDMPYRAAAL SATSAGRYIY ISGGTTEQIS GLKTAWRYDM DDNSWTKLPD LPIGLVFHTM VTCGGTVYSV GGSIAPRRYV SNIYRYDERK EVWCLAGKMS IPMDGTAVIT KGDRHLYIVT GRCLVKGYIS RVGVVDCFDT STGDVVQCIT FPIEFNHRPL LSFQQDNILC VHSHRQSVEI NLQKVKASKT TTSVPVLPNS CPLDVSHAIC SIGDSKVFVC GGVTTASDVQ TKDYTINPNA FLLDQKTGKW KTLAPPPEAL DCPACCLAKL PCKILQRI
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a basic protein of the sperm head cytoskeleton. This protein contains kelch repeats and a BTB/POZ domain and is necessary for normal morphology during sperm differentiation. This gene is intronless.

References

Lecuyer, C., et al. Biol. Reprod. 63(6):1801-1810(2000)
von Bulow, M., et al. Exp. Cell Res. 219(2):407-413(1995)

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$ 295.00
$ 99.00
Cat# AP17618c
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(40 western blots)
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