|Application ||WB, E|
|Other Accession||Q8C4Q6, Q4R8C7, Q6PBN2, NP_073742.2|
|Predicted||Zebrafish, Monkey, Mouse|
|Calculated MW||35023 Da|
|Antigen Region||255-283 aa|
|Other Names||Axin interactor, dorsalization-associated protein, Axin interaction partner and dorsalization antagonist, AIDA, C1orf80|
|Target/Specificity||This AIDA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-283 amino acids from the C-terminal region of human AIDA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AIDA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).|
|Tissue Location||Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
AIDA acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).
Rui, Y., et al. Dev. Cell 13(2):268-282(2007)
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