|Application ||WB, E|
|Other Accession||P78410, O00481, NP_932078.2|
|Calculated MW||65002 Da|
|Antigen Region||67-96 aa|
|Other Names||Butyrophilin subfamily 3 member A3, BTN3A3, BTF3|
|Target/Specificity||This BTN3A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human BTN3A3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BTN3A3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in T-cell responses in the adaptive immune response.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in peripheral blood mononuclear cells and in T-cells (at protein level). Detected in spleen and lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM].
Smith, I.A., et al. J. Immunol. 184(7):3514-3525(2010)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Rhodes, D.A., et al. Genomics 71(3):351-362(2001)
Henry, J., et al. Immunol. Today 20(6):285-288(1999)
Ruddy, D.A., et al. Genome Res. 7(5):441-456(1997)
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