|Application ||WB, E|
|Other Accession||Q8VCL2, A6H784, NP_001162581.1|
|Calculated MW||29810 Da|
|Antigen Region||196-224 aa|
|Other Names||Protein SCO2 homolog, mitochondrial, SCO2|
|Target/Specificity||This SCO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the C-terminal region of human SCO2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SCO2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).|
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Provided below are standard protocols that you may find useful for product applications.
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX asembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Foltopoulou, P.F., et al. Biochim. Biophys. Acta 1802(6):497-508(2010)
Pronicki, M., et al. Eur. J. Paediatr. Neurol. 14(3):253-260(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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