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SCO2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O43819 |
| Other Accession | Q8VCL2, A6H784, NP_001162581.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 29810 Da |
| Antigen Region | 196-224 aa |
| Gene ID | 9997 |
|---|---|
| Other Names | Protein SCO2 homolog, mitochondrial, SCO2 |
| Target/Specificity | This SCO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the C-terminal region of human SCO2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SCO2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SCO2 |
|---|---|
| Function | Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15229189, PubMed:17189203). Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2 (PubMed:19336478). |
| Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein |
| Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX asembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Foltopoulou, P.F., et al. Biochim. Biophys. Acta 1802(6):497-508(2010)
Pronicki, M., et al. Eur. J. Paediatr. Neurol. 14(3):253-260(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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