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SHOC2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SHOC2 Antibody (N-term) AP17667a
    SHOC2 Antibody (N-term) (Cat. #AP17667a) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SHOC2 antibody detected the SHOC2 protein (arrow).
  • WB - SHOC2 Antibody (N-term) AP17667a
    SHOC2 Antibody (N-term) (Cat. #AP17667a) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the SHOC2 antibody detected the SHOC2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UQ13
Other Accession O88520, A6QLV3, NP_031399.2
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 64888 Da
Antigen Region 56-83 aa
Additional Information
Gene ID 8036
Other Names Leucine-rich repeat protein SHOC-2, Protein soc-2 homolog, Protein sur-8 homolog, SHOC2, KIAA0862
Target/Specificity This SHOC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-83 amino acids from the N-terminal region of human SHOC2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSHOC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SHOC2
Synonyms KIAA0862
Function Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Cellular Location Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation
Research Areas
Citations (0)

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This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair.


Matsunaga-Udagawa, R., et al. J. Biol. Chem. 285(10):7818-7826(2010)
Yoshiki, S., et al. Mol. Biol. Cell 21(6):1088-1096(2010)
Flotho, C., et al. Blood 115 (4), 913 (2010) :
Cordeddu, V., et al. Nat. Genet. 41(9):1022-1026(2009)
Rodriguez-Viciana, P., et al. Mol. Cell 22(2):217-230(2006)

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$ 295.00
$ 99.00
Cat# AP17667a
(40 western blots)
Availability: In Stock
Bulk Size
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