TOX4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O94842 |
Other Accession | NP_055643.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 66195 Da |
Antigen Region | 172-199 aa |
Gene ID | 9878 |
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Other Names | TOX high mobility group box family member 4, Epidermal Langerhans cell protein LCP1, TOX4, C14orf92, KIAA0737 |
Target/Specificity | This TOX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-199 amino acids from the N-terminal region of human TOX4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TOX4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TOX4 (HGNC:20161) |
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Synonyms | C14orf92, KIAA0737 |
Function | Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation (By similarity). |
Cellular Location | Nucleus. Note=Associated with chromatin |
Tissue Location | Expressed in liver (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
TOX4 (TOX high mobility group box family member 4) contains 1 HMG box DNA-binding domain and the function remains unknown.
References
Lee, J.H., et al. J. Biol. Chem. 285(32):24466-24476(2010)
Lee, S.J., et al. Exp. Mol. Med. 41(3):189-200(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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