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MPZL2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O60487 |
| Other Accession | NP_005788.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24484 Da |
| Antigen Region | 67-94 aa |
| Gene ID | 10205 |
|---|---|
| Other Names | Myelin protein zero-like protein 2, Epithelial V-like antigen 1, MPZL2, EVA, EVA1 |
| Target/Specificity | This MPZL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the Central region of human MPZL2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MPZL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MPZL2 |
|---|---|
| Synonyms | EVA {ECO:0000303|PubMed:9585423}, EVA1 |
| Function | Mediates homophilic cell-cell adhesion. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Widely expressed. In fetal tissues, highest expression in the inner ear. In adult tissues, highest levels in thymus and lung. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
References
Kim, H., et al. Pharmacogenomics 10(2):171-179(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Guttinger, M., et al. J. Cell Biol. 141(4):1061-1071(1998)
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