|Application ||WB, E|
|Other Accession||Q499U2, Q8BYZ7, A6QR40, NP_078988.2|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||81467 Da|
|Antigen Region||594-622 aa|
|Other Names||Engulfment and cell motility protein 3, ELMO3|
|Target/Specificity||This ELMO3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 594-622 amino acids from the C-terminal region of human ELMO3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ELMO3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes.
Coskun, M., et al. J. Cell. Biochem. 109(6):1118-1128(2010)
Gumienny, T.L., et al. Cell 107(1):27-41(2001)
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