|Application ||WB, E|
|Calculated MW||31299 Da|
|Antigen Region||252-278 aa|
|Other Names||Gap junction gamma-3 protein, Connexin-302, Cx302, Connexin-313, Cx313, Gap junction epsilon-1 protein, GJC3, GJE1|
|Target/Specificity||This GJC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-278 amino acids from the C-terminal region of human GJC3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GJC3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction|
|Tissue Location||CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve. According to PubMed:12881038, expression is abundant in skeletal muscle, liver, and heart, and to a minor degree in pancreas and kidney|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a gap junction protein. The encoded protein, also known as a connexin, plays a role in formation of gap junctions, which provide direct connections between neighboring cells. Mutations in this gene have been reported to be associated with nonsyndromic hearing loss.
Yang, J.J., et al. Hum. Genet. 128(3):303-313(2010)
Ramchander, P.V., et al. Genet Test Mol Biomarkers 14(4):539-541(2010)
Hong, H.M., et al. Hum. Genet. 127(2):191-199(2010)
Wang, W.H., et al. Audiol. Neurootol. 15(2):81-87(2010)
Sargiannidou, I., et al. Neurobiol. Dis. 30(2):221-233(2008)
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