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>   home   >   Products   >   Primary Antibodies   >   AKIR1 Antibody (C-term)   

AKIR1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - AKIR1 Antibody (C-term) AP17755B
    Western blot analysis of AKIR1 Antibody (C-term) (Cat. #AP17755b) in Hela cell line lysates (35ug/lane).AKIR1 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H9L7
Other Accession NP_078871.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 21867 Da
Antigen Region 131-158 aa
Additional Information
Gene ID 79647
Other Names Akirin-1, AKIRIN1, C1orf108
Target/Specificity This AKIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-158 amino acids from the C-terminal region of human AKIR1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAKIR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C1orf108
Cellular Location Nucleus.
Tissue Location Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes
Citations (0)

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The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways. AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.


Goto, A., et al. Nat. Immunol. 9(1):97-104(2008)

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$ 295.00
$ 99.00
Cat# AP17755B
(40 western blots)
Availability: In Stock
Bulk Size
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