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NOTUM Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6P988 |
| Other Accession | NP_848588.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55699 Da |
| Antigen Region | 353-379 aa |
| Gene ID | 147111 |
|---|---|
| Other Names | Protein notum homolog, 3---, NOTUM |
| Target/Specificity | This NOTUM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-379 amino acids from the C-terminal region of human NOTUM. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NOTUM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NOTUM (HGNC:27106) |
|---|---|
| Function | Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:Q9VUX3}. |
| Tissue Location | Rarely expressed in adult normal tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NOTUM may deacetylate GlcNAc residues on cell surface glycans (Potential).
References
Torisu, Y., et al. Cancer Sci. 99(6):1139-1146(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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