|Application ||WB, E|
|Calculated MW||78632 Da|
|Antigen Region||396-423 aa|
|Other Names||TRAF3-interacting protein 1, Interleukin-13 receptor alpha 1-binding protein 1, Intraflagellar transport protein 54 homolog, Microtubule-interacting protein associated with TRAF3, MIP-T3, TRAF3IP1, IFT54, MIPT3|
|Target/Specificity||This TRAF3IP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-423 amino acids from the Central region of human TRAF3IP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRAF3IP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, cilium. Note=Microtubules|
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Provided below are standard protocols that you may find useful for product applications.
TRAF3IP1 play an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Guo, C.W., et al. Proteomics 10(12):2337-2347(2010)
Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)
Tomppo, L., et al. Biol. Psychiatry 65(12):1055-1062(2009)
Camargo, L.M., et al. Mol. Psychiatry 12(1):74-86(2007)
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