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CALCRL Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | Q16602 |
| Other Accession | Q8WN93, NP_005786.1 |
| Reactivity | Human |
| Predicted | Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52979 Da |
| Antigen Region | 340-367 aa |
| Gene ID | 10203 |
|---|---|
| Other Names | Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor, CALCRL, CGRPR |
| Target/Specificity | This CALCRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-367 amino acids from the Central region of human CALCRL. |
| Dilution | WB~~1:1000 IHC-P-Leica~~1:500 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CALCRL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CALCRL (HGNC:16709) |
|---|---|
| Synonyms | CGRPR |
| Function | Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2 (PubMed:22102369, PubMed:30115739). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:22102369, PubMed:30115739). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Predominantly expressed in the lung and heart. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kuwasako, K., et al. Biochem. Biophys. Res. Commun. 392(3):380-385(2010)
Chang, C.L., et al. J. Biol. Chem. 285(2):1075-1080(2010)
Barwell, J., et al. Peptides 31(1):170-176(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
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