|Application ||WB, E|
|Other Accession||Q8WN93, NP_005786.1|
|Calculated MW||52929 Da|
|Antigen Region||340-367 aa|
|Other Names||Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor, CALCRL, CGRPR|
|Target/Specificity||This CALCRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-367 amino acids from the Central region of human CALCRL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CALCRL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Predominantly expressed in the lung and heart.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kuwasako, K., et al. Biochem. Biophys. Res. Commun. 392(3):380-385(2010)
Chang, C.L., et al. J. Biol. Chem. 285(2):1075-1080(2010)
Barwell, J., et al. Peptides 31(1):170-176(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
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