|Application ||WB, E|
|Calculated MW||150701 Da|
|Antigen Region||1295-1323 aa|
|Other Names||Adenylate cyclase type 9, ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, Adenylyl cyclase 9, ADCY9, KIAA0520|
|Target/Specificity||This ADCY9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1295-1323 amino acids from the C-terminal region of human ADCY9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADCY9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein- coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:9628827, PubMed:10987815). Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952)|
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Provided below are standard protocols that you may find useful for product applications.
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.
Wojcik, C., et al. Am. J. Med. Genet. A 152A (2), 479-483 (2010) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Tantisira, K.G., et al. Hum. Mol. Genet. 14(12):1671-1677(2005)
Cumbay, M.G., et al. J. Pharmacol. Exp. Ther. 310(1):108-115(2004)
Small, K.M., et al. Pharmacogenetics 13(9):535-541(2003)
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