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SERTAD2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q14140 |
| Other Accession | Q9JJG5, NP_055570.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33897 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 9792 |
|---|---|
| Other Names | SERTA domain-containing protein 2, Transcriptional regulator interacting with the PHD-bromodomain 2, TRIP-Br2, SERTAD2, KIAA0127 |
| Target/Specificity | This SERTAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SERTAD2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SERTAD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SERTAD2 |
|---|---|
| Synonyms | KIAA0127, TRIPBR2 |
| Function | Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. |
| Cellular Location | Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome |
| Tissue Location | Expressed in adipose tissue. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SERTAD2 acts at E2F-responsive promoters to integrate signals provided by PHD-and/or bromodomain-containing transcription factors (By similarity).
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Cheong, J.K., et al. J Transl Med 7, 8 (2009) :
Cheong, J.K., et al. J. Biol. Chem. 283(17):11661-11676(2008)
Watanabe-Fukunaga, R., et al. Genes Cells 10(8):851-860(2005)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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