|Application ||WB, E|
|Calculated MW||57464 Da|
|Antigen Region||388-414 aa|
|Other Names||Acid-sensing ion channel 5, ASIC5, Amiloride-sensitive cation channel 5, Human intestine Na(+) channel, HINaC, ASIC5, ACCN5, HINAC|
|Target/Specificity||This ACCN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 388-414 amino acids from the C-terminal region of human ACCN5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACCN5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in small intestine, duodenum and jejunum. Detected at very low levels in testis and rectum|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known.
Schaefer, L., et al. FEBS Lett. 471 (2-3), 205-210 (2000) :
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