|Application ||WB, E|
|Calculated MW||55392 Da|
|Antigen Region||34-60 aa|
|Other Names||tRNA-specific adenosine deaminase 1, hADAT1, tRNA-specific adenosine-37 deaminase, ADAT1|
|Target/Specificity||This ADAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-60 amino acids from the N-terminal region of human ADAT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADAT1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specifically deaminates adenosine-37 to inosine in tRNA- Ala.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described.
Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)
Maas, S., et al. Proc. Natl. Acad. Sci. U.S.A. 96(16):8895-8900(1999)
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