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HHIP Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96QV1 |
| Other Accession | Q7TN16, NP_071920.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 78851 Da |
| Antigen Region | 25-54 aa |
| Gene ID | 64399 |
|---|---|
| Other Names | Hedgehog-interacting protein, HHIP, HIP, HHIP, HIP |
| Target/Specificity | This HHIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human HHIP. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HHIP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HHIP |
|---|---|
| Synonyms | HIP |
| Function | Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. |
| Cellular Location | Cell membrane; Peripheral membrane protein. Secreted. Note=The last 22 C- terminal amino acids may participate in cell membrane attachment |
| Tissue Location | Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney. {ECO:0000269|PubMed:11435703, ECO:0000269|Ref.1} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein similar to the mouse hedgehog-interacting protein, a regulatory component of the hedgehog signalling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.
References
Pillai, S.G., et al. Am. J. Respir. Crit. Care Med. (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Liu, J.Z., et al. Twin Res Hum Genet 13(2):179-193(2010)
Cho, M.H., et al. Nat. Genet. 42(3):200-202(2010)
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
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